Melittin - the main component of bee venom: a promising therapeutic agent for neuroprotection through keap1/Nrf2/HO-1 pathway activation
Cong Duc Nguyen, Jaehee Yoo, Sang Jun Jeong, Hai-Anh Ha, Ji Hye Yang, Gihyun Lee, Jeong Cheol Shin, Jae-Hong Kim · 2024
Read Melittin - the main component of bee venom: a promising therapeutic agent for neuroprotection through keap1/Nrf2/HO-1 pathway activation by Cong Duc Nguyen, Jaehee Yoo, Sang Jun Jeong, Hai-Anh Ha, Ji Hye Yang, Gihyun Lee, Jeong Cheol Shin, Jae-Hong Kim (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11603938.txt.
Description
Cong Duc Nguyen and co-authors test whether melittin, the main active part of bee venom, can protect the brain, in a 2024 study. The work centers on a defense pathway in cells that switches on antioxidant protection. In stressed mice, that pathway was weak. The team gave melittin to mice whose memory had been harmed by the drug scopolamine and tracked what changed in the brain over time.
Melittin crossed the weakened blood-brain barrier and built up in the hippocampus, a region tied to memory. Within about five hours, the defense pathway was restored and oxidative stress fell. Over the next hours, inflammation, cell death signals, and tissue energy levels also improved, and the mice did better on maze tests. The findings point to a timed sequence behind the protective effect.
Catalog record
| CREATOR | Cong Duc Nguyen, Jaehee Yoo, Sang Jun Jeong, Hai-Anh Ha, Ji Hye Yang, Gihyun Lee, Jeong Cheol Shin, Jae-Hong Kim |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 84 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |