Engrailed-2 and inflammation convergently and independently impinge on cerebellar Purkinje cell differentiation
Mohammed Bahaaeldin, Carolin Bülte, Fabienne Luelsberg, Sujeet Kumar, Joachim Kappler, Christof Völker, Karl Schilling, Stephan L Baader · 2024
Read Engrailed-2 and inflammation convergently and independently impinge on cerebellar Purkinje cell differentiation by Mohammed Bahaaeldin, Carolin Bülte, Fabienne Luelsberg, Sujeet Kumar, Joachim Kappler, Christof Völker, Karl Schilling, Stephan L Baader (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11603920.txt.
Description
Autism risk seems to mix genes with outside triggers such as inflammation in the young brain, but how the two meet is unclear. Bahaaeldin and co-authors used slices of young cerebellum in culture to test one meeting point: Purkinje cells, the large neurons that organize the cerebellum. They added a bacterial compound that sparks inflammation, with and without extra copies of Engrailed-2, a gene tied to autism.
The inflammation shrank the branching of these cells, and the extra gene copies made the shrinkage worse. Blocking microglia growth or one key inflammation signal undid the harm, which names those players as the route. The findings cast Purkinje cells as a place where genes and environment add up.
Catalog record
| CREATOR | Mohammed Bahaaeldin, Carolin Bülte, Fabienne Luelsberg, Sujeet Kumar, Joachim Kappler, Christof Völker, Karl Schilling, Stephan L Baader |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |