CAFs-derived lactate enhances the cancer stemness through inhibiting the MST1 ubiquitination degradation in OSCC
Shuzhen Zhang, Jingjing Wang, Yang Chen, Weilian Liang, Hanzhe Liu, Ruixue Du, Yunqing Sun, Chuanyu Hu, Zhengjun Shang · 2024
Read CAFs-derived lactate enhances the cancer stemness through inhibiting the MST1 ubiquitination degradation in OSCC by Shuzhen Zhang, Jingjing Wang, Yang Chen, Weilian Liang, Hanzhe Liu, Ruixue Du, Yunqing Sun, Chuanyu Hu, Zhengjun Shang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11603751.txt.
Description
Shuzhen Zhang and co-authors report a 2024 study on mouth cancer and the helper cells that surround tumors. Those helper cells, called cancer-associated fibroblasts, feed tumors and shape their growth. In oral squamous cell carcinoma, they also seem to boost the stem-like cells that help cancers persist and return.
The team found the helper cells burn more sugar and release more lactic acid. That acid raised stem cell markers in cancer cells and helped them form spheres and colonies. Gene tests pointed to a protein, DLG5, and a growth control path named Hippo. Through a chain of proteins, the acid shields a key Hippo protein from being broken down. Cutting the acid trade between the cell types may weaken the cancer.
Catalog record
| CREATOR | Shuzhen Zhang, Jingjing Wang, Yang Chen, Weilian Liang, Hanzhe Liu, Ruixue Du, Yunqing Sun, Chuanyu Hu, Zhengjun Shang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |