Highly efficient generation of mature megakaryocytes and functional platelets from human embryonic stem cells
Chuxin Chen, Ning Wang, Xueyan Zhang, Yingjie Fu, Zhiyong Zhong, Haibin Wu, Yaming Wei, Yuyou Duan · 2024
Read Highly efficient generation of mature megakaryocytes and functional platelets from human embryonic stem cells by Chuxin Chen, Ning Wang, Xueyan Zhang, Yingjie Fu, Zhiyong Zhong, Haibin Wu, Yaming Wei, Yuyou Duan (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11603724.txt.
Description
Chuxin Chen and co-authors grow platelet-producing cells from human embryonic stem cells at high efficiency in a 2024 paper. Platelet transfusions save lives, but supply depends on donors. Stem-cell-derived platelets could become an alternative source if they can be made mature and functional at scale.
Under low-oxygen conditions, the team replayed the natural maturation steps with a tuned sequence of growth factors in a three-dimensional system. The resulting giant parent cells showed the right surface markers at rates above ninety percent, carried many chromosome sets, and shed filamentous arms that release platelets. The platelets bore active markers and were checked by many methods. In mice lacking platelets, the lab-made ones functioned in the body.
Catalog record
| CREATOR | Chuxin Chen, Ning Wang, Xueyan Zhang, Yingjie Fu, Zhiyong Zhong, Haibin Wu, Yaming Wei, Yuyou Duan |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |