Searching for the ‘X’ factor: investigating the genetics of primary ovarian insufficiency
Anya Knight, Sara Sugin, Andrea Jurisicova · 2024
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Description
Anya Knight, Sara Sugin, and Andrea Jurisicova review, in 2024 work, why ovaries may stop working before age forty. That early stop has many causes, but genes play a clear part, above all genes on the X chromosome. The team searched past reports for such genes and for signs of what they do in the body.
Ten X-linked genes had changes tied to real cases in women. Ten more looked likely to play a part, based on work in mice or on their role in fertility. In many cases, whole-genome scans found more than one change at once. The reviewers say the one gene now checked in clinics is far too few. Wider gene tests, they argue, could lead to earlier care and better advice.
Catalog record
| CREATOR | Anya Knight, Sara Sugin, Andrea Jurisicova |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |