Inhibition of IRE1α/XBP1 axis alleviates LPS-induced acute lung injury by suppressing TXNIP/NLRP3 inflammasome activation and ERK/p65 signaling pathway
Sijiao Wang, Lijuan Hu, Yipeng Fu, Fan Xu, Yue Shen, Hanhan Liu, Lei Zhu · 2024
Read Inhibition of IRE1α/XBP1 axis alleviates LPS-induced acute lung injury by suppressing TXNIP/NLRP3 inflammasome activation and ERK/p65 signaling pathway by Sijiao Wang, Lijuan Hu, Yipeng Fu, Fan Xu, Yue Shen, Hanhan Liu, Lei Zhu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11603636.txt.
Description
Sijiao Wang and co-authors show that blocking a cell stress axis eases acute lung injury in mice. The IRE1α-XBP1 path is one of three arms of the endoplasmic reticulum stress response. Bacterial toxin blown into the airway built the injury model. Blocking the axis with a drug called 4µ8C notably softened the damage.
Lung tissue looked cleaner, and inflammatory signals IL-6, IL-1β, and TNF-α fell. Cell death and inflammasome firing dropped in step. In human airway cells, the drug and gene silencing both cut the same signals. Two signaling routes, ERK and p65, quieted as the mechanism. The axis stands out as a drug target for this syndrome.
Catalog record
| CREATOR | Sijiao Wang, Lijuan Hu, Yipeng Fu, Fan Xu, Yue Shen, Hanhan Liu, Lei Zhu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |