Downregulation of Notch Signaling‐Stimulated Genes in Neurovascular Unit Alterations Induced by Chronic Cerebral Hypoperfusion
Dewen Ru, Zengyu Zhang, Meng Liu, Xuhui Fan, Yuqi Wang, Yufeng Yan, Ersong Wang · 2024
Read Downregulation of Notch Signaling‐Stimulated Genes in Neurovascular Unit Alterations Induced by Chronic Cerebral Hypoperfusion by Dewen Ru, Zengyu Zhang, Meng Liu, Xuhui Fan, Yuqi Wang, Yufeng Yan, Ersong Wang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11603426.txt.
Description
BackgroundChronic cerebral hypoperfusion (CCH) is a key contributor to vascular cognitive impairment (VCI) and is typically associated with blood–brain barrier (BBB) damage. This study investigates the pathological mechanisms underlying CCH‐induced neurovascular unit (NVU) alterations.MethodsA mouse model of CCH was established using the bilateral common carotid artery stenosis (BCAS) procedure. Decreased cerebral blood flow (CBF) and impaired BBB integrity were assessed.
Catalog record
| CREATOR | Dewen Ru, Zengyu Zhang, Meng Liu, Xuhui Fan, Yuqi Wang, Yufeng Yan, Ersong Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |