Postmortem analyses of myocardial microRNA expression in sepsis
Pasi Lehto, Sini Skarp, Taru Saukko, Hanna Säkkinen, Hannu Syrjälä, Risto Kerkelä, Samu Saarimäki, Sonja Bläuer, Katja Porvari, Lasse Pakanen, Jaana Karhu, Tero Ala-Kokko · 2024
Read Postmortem analyses of myocardial microRNA expression in sepsis by Pasi Lehto, Sini Skarp, Taru Saukko, Hanna Säkkinen, Hannu Syrjälä, Risto Kerkelä, Samu Saarimäki, Sonja Bläuer, Katja Porvari, Lasse Pakanen, Jaana Karhu, Tero Ala-Kokko (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11603066.txt.
Description
Pasi Lehto and co-authors study tiny RNA signals in heart tissue after death from sepsis in a 2024 paper. Sepsis can depress heart function, and that weakness shapes patient outcomes. The molecular switches behind the heart's response remain only partly understood.
The team took heart samples at autopsy from fifteen patients who died with sepsis. Control tissue came from fifteen medicolegal cases with other causes of death. They extracted RNA from preserved samples and compared microRNA levels between groups. Statistical tools flagged which small RNAs differed. Such differences may reveal how sepsis rewires heart cells. The postmortem approach offers a rare direct look at human heart tissue in fatal illness.
Catalog record
| CREATOR | Pasi Lehto, Sini Skarp, Taru Saukko, Hanna Säkkinen, Hannu Syrjälä, Risto Kerkelä, Samu Saarimäki, Sonja Bläuer, Katja Porvari, Lasse Pakanen, Jaana Karhu, Tero Ala-Kokko |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |