Photoacoustic polydopamine-indocyanine green (PDA-ICG) nanoprobe for detection of senescent cells
Muhamad Hartono, Andrew G Baker, Thomas R Else, Alexander S Evtushenko, Sarah E Bohndiek, Daniel Muñoz-Espín, Ljiljana Fruk · 2024
Read Photoacoustic polydopamine-indocyanine green (PDA-ICG) nanoprobe for detection of senescent cells by Muhamad Hartono, Andrew G Baker, Thomas R Else, Alexander S Evtushenko, Sarah E Bohndiek, Daniel Muñoz-Espín, Ljiljana Fruk (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11603024.txt.
Description
Hartono and co-authors build a tiny probe that lights up aged cells for a sound-based imaging method. Aged, or senescent, cells can suppress tumors early on, yet when they linger they help cancers grow, resist drugs, and return. Their 2024 probe wraps a safe black polymer particle around an approved green dye, making a contrast agent that aged cells take up more readily.
In dishes, cells aged by chemotherapy took up more of the probe than cancer cells did. The probe also held its signal under light better than the free dye and gave a signal about two and a half times stronger. The authors say the probe could help doctors spot senescent cells in the body. That skill could aid early cancer warnings and judging of anti-aging cell therapies.
Catalog record
| CREATOR | Muhamad Hartono, Andrew G Baker, Thomas R Else, Alexander S Evtushenko, Sarah E Bohndiek, Daniel Muñoz-Espín, Ljiljana Fruk |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |