Preparation and characterizations of chitosan–octanoate nanoparticles for efficient delivery of curcumin into prostate cancer cells
Ahmad Bani-Jaber, Safaa Taha, Rana Abu-Dahab, Samaa Abdullah, Dina El-Sabawi, Alaa A Al-Masud, Alhassan H Aodah, Abeer A Altamimi · 2024
Read Preparation and characterizations of chitosan–octanoate nanoparticles for efficient delivery of curcumin into prostate cancer cells by Ahmad Bani-Jaber, Safaa Taha, Rana Abu-Dahab, Samaa Abdullah, Dina El-Sabawi, Alaa A Al-Masud, Alhassan H Aodah, Abeer A Altamimi (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11602931.txt.
Description
Ahmad Bani-Jaber and seven co-authors build tiny carriers to ferry a spice compound into prostate cancer cells, in a 2024 study. The carrier starts from chitosan, a shell-derived sugar chain, tweaked with a fatty tail so it forms spheres in water. The compound, curcumin, kills cancer cells in dishes but dissolves poorly. Loading it into the spheres could help it reach its targets.
The loaded spheres measured about 270 nanometers wide and trapped roughly three fifths of the compound. Imaging and X-ray tests showed the drug lost its crystal form inside the spheres, which often helps it dissolve. Empty spheres alone slowed cancer cell growth somewhat, an effect the team ties to cell uptake of the carrier. Loaded spheres killed more still, across two prostate cancer lines. The authors see the platform as a base for carrying other cancer drugs as well.
Catalog record
| CREATOR | Ahmad Bani-Jaber, Safaa Taha, Rana Abu-Dahab, Samaa Abdullah, Dina El-Sabawi, Alaa A Al-Masud, Alhassan H Aodah, Abeer A Altamimi |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |