Open-lung ventilation versus no ventilation during cardiopulmonary bypass in an innovative animal model of heart transplantation
Varun Karnik, Sebastiano Maria Colombo, Leah Rickards, Silver Heinsar, Louise E See Hoe, Karin Wildi, Margaret R Passmore, Mahe Bouquet, Kei Sato, Carmen Ainola, Nicole Bartnikowski, Emily S Wilson, Kieran Hyslop, Kris Skeggs, Nchafatso G Obonyo, Charles McDonald, Samantha Livingstone, Gabriella Abb · 2024
Read Open-lung ventilation versus no ventilation during cardiopulmonary bypass in an innovative animal model of heart transplantation by Varun Karnik, Sebastiano Maria Colombo, Leah Rickards, Silver Heinsar, Louise E See Hoe, Karin Wildi, Margaret R Passmore, Mahe Bouquet, Kei Sato, Carmen Ainola, Nicole Bartnikowski, Emily S Wilson, Kieran Hyslop, Kris Skeggs, Nchafatso G Obonyo, Charles McDonald, Samantha Livingstone, Gabriella Abb (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11602927.txt.
Description
Varun Karnik and co-authors test lung ventilation during heart bypass in a 2024 sheep study. During transplant surgery, the heart-lung machine takes over and lungs often rest still. That rest may seed later lung injury. An open-lung strategy keeps gentle air flowing instead.
Eighteen sheep in a transplant model were split by chance. One group got low-volume breaths with airway pressure held. The other got no ventilation, the usual care. Six hours of post-surgery watch followed. Tissue damage scores, the main outcome, ran lower in the ventilated group. Gas exchange, pressures, and inflammation markers fill out the picture. The model supports a human trial.
Catalog record
| CREATOR | Varun Karnik, Sebastiano Maria Colombo, Leah Rickards, Silver Heinsar, Louise E See Hoe, Karin Wildi, Margaret R Passmore, Mahe Bouquet, Kei Sato, Carmen Ainola, Nicole Bartnikowski, Emily S Wilson, Kieran Hyslop, Kris Skeggs, Nchafatso G Obonyo, Charles McDonald, Samantha Livingstone, Gabriella Abb |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |