NLRP3 activation maintains intestinal epithelial barrier and reduces liver injury in alcoholic liver disease mice
Shi‐Qing Li, Ya‐Ru Wang, Zhong‐Liang Xie, Yan Wang, Zi‐Han Feng, Jian‐Hao Xu, Bing Yuan, Yi‐Tong Zhang, Guan Yang, Jing‐Lin Wang, Yuan Yuan · 2024
Read NLRP3 activation maintains intestinal epithelial barrier and reduces liver injury in alcoholic liver disease mice by Shi‐Qing Li, Ya‐Ru Wang, Zhong‐Liang Xie, Yan Wang, Zi‐Han Feng, Jian‐Hao Xu, Bing Yuan, Yi‐Tong Zhang, Guan Yang, Jing‐Lin Wang, Yuan Yuan (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11602754.txt.
Description
Shi-Qing Li and co-authors published a 2024 study on the gut barrier in alcoholic liver disease, using mice. People with this disease often die from infections, and a leaky gut is suspected to help germs slip into the body. The team focused on a protein complex called NLRP3, part of the immune alarm system in the gut lining.
Mice fed alcohol over a long period showed a weaker gut barrier: key sealing proteins fell, while alarm proteins rose. Mice bred without NLRP3, or without its partner protein, fared worse still. Their guts carried more bacteria, their gut inflammation was stronger, and their livers suffered more damage. Germs also leaked more readily into the blood in these mice. The results suggest the alarm complex, though part of inflammation, actually protects the gut wall early in the disease. Losing it opens the door to infection.
Catalog record
| CREATOR | Shi‐Qing Li, Ya‐Ru Wang, Zhong‐Liang Xie, Yan Wang, Zi‐Han Feng, Jian‐Hao Xu, Bing Yuan, Yi‐Tong Zhang, Guan Yang, Jing‐Lin Wang, Yuan Yuan |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |