The gut microbiota‐derived metabolite indole‐3‐propionic acid enhances leptin sensitivity by targeting STAT3 against diet‐induced obesity
Zhiwei Wang, Shaying Yang, Liangju Liu, Aiqin Mao, Hao Kan, Fan Yu, Xin Ma, Lei Feng, Tingting Zhou · 2024
Read The gut microbiota‐derived metabolite indole‐3‐propionic acid enhances leptin sensitivity by targeting STAT3 against diet‐induced obesity by Zhiwei Wang, Shaying Yang, Liangju Liu, Aiqin Mao, Hao Kan, Fan Yu, Xin Ma, Lei Feng, Tingting Zhou (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11602751.txt.
Description
Zhiwei Wang and co-authors report a gut based path to weight control in a 2024 study. A compound made by gut bacteria from a food amino acid helps the body respond to leptin, a hormone that curbs hunger. In mice fed a fat rich diet, levels of that compound fall.
Giving the compound or the bacteria that make it curbed weight gain in those mice and improved blood sugar control. It worked by binding a key protein in the brain center that guides hunger. It failed in mice that lack leptin, and adding leptin brought the effect back. The work points to a gut to brain route that could aid care for obesity.
Catalog record
| CREATOR | Zhiwei Wang, Shaying Yang, Liangju Liu, Aiqin Mao, Hao Kan, Fan Yu, Xin Ma, Lei Feng, Tingting Zhou |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |