Insights into RNA‐mediated pathology in new mouse models of Huntington's disease
Magdalena Wozna‐Wysocka, Magdalena Jazurek‐Ciesiolka, Lukasz Przybyl, Dorota Wronka, Julia Oliwia Misiorek, Joanna Suszynska‐Zajczyk, Grzegorz Figura, Adam Ciesiolka, Paula Sobieszczanska, Anna Zeller, Magdalena Niemira, Pawel Michal Switonski, Agnieszka Fiszer · 2024
Read Insights into RNA‐mediated pathology in new mouse models of Huntington's disease by Magdalena Wozna‐Wysocka, Magdalena Jazurek‐Ciesiolka, Lukasz Przybyl, Dorota Wronka, Julia Oliwia Misiorek, Joanna Suszynska‐Zajczyk, Grzegorz Figura, Adam Ciesiolka, Paula Sobieszczanska, Anna Zeller, Magdalena Niemira, Pawel Michal Switonski, Agnieszka Fiszer (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11602643.txt.
Description
Polish researchers built two mouse models to test whether faulty RNA alone can drive part of Huntington disease. The disease stems from a stretched repeat in one gene, which makes a harmful protein. Whether the gene RNA copy harms cells on its own, apart from the protein, has long been debated. One mouse line made both the RNA and the protein, while a second made the RNA in a form that cells could not turn into protein.
Both lines were tracked for 21 months with tests of movement, thought, and gene activity. Both showed changes in behaviour and in gene use in a key brain area. The line with the protein showed a late, fuller disease pattern. Mice with RNA alone still showed motor flaws in some tests and odd activity at night. The work backs a real, if smaller, role for RNA harm.
Catalog record
| CREATOR | Magdalena Wozna‐Wysocka, Magdalena Jazurek‐Ciesiolka, Lukasz Przybyl, Dorota Wronka, Julia Oliwia Misiorek, Joanna Suszynska‐Zajczyk, Grzegorz Figura, Adam Ciesiolka, Paula Sobieszczanska, Anna Zeller, Magdalena Niemira, Pawel Michal Switonski, Agnieszka Fiszer |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 86 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |