An IL-2 mutein increases regulatory T cell suppression of dendritic cells via IL-10 and CTLA-4 to promote T cell anergy
Braxton L. Jamison, Matthew Lawrance, Chun Jing Wang, Hannah A. DeBerg, Lauren J. Ziegler, David M. Sansom, Marc A. Gavin, Lucy S.K. Walker, Daniel J. Campbell · 2024
Read An IL-2 mutein increases regulatory T cell suppression of dendritic cells via IL-10 and CTLA-4 to promote T cell anergy by Braxton L. Jamison, Matthew Lawrance, Chun Jing Wang, Hannah A. DeBerg, Lauren J. Ziegler, David M. Sansom, Marc A. Gavin, Lucy S.K. Walker, Daniel J. Campbell (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11602548.txt.
Description
SummaryInterleukin-2 (IL-2) variants with increased CD25 dependence that selectively expand Foxp3+ regulatory T (TR) cells are in clinical trials for treating inflammatory diseases. Using an Fc-fused IL-2 mutein (Fc.IL-2 mutein) we developed that prevents diabetes in non-obese diabetic (NOD) mice, we show that Fc.
Catalog record
| CREATOR | Braxton L. Jamison, Matthew Lawrance, Chun Jing Wang, Hannah A. DeBerg, Lauren J. Ziegler, David M. Sansom, Marc A. Gavin, Lucy S.K. Walker, Daniel J. Campbell |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 87 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |