The ubiquitous pyridoxal 5′‐phosphate‐binding protein is also an RNA‐binding protein
Claudio Graziani, Anna Barile, Alessia Parroni, Martino Luigi di Salvo, Irene De Cecio, Teresa Colombo, Jill Babor, Valérie de Crécy‐Lagard, Roberto Contestabile, Angela Tramonti · 2024
Read The ubiquitous pyridoxal 5′‐phosphate‐binding protein is also an RNA‐binding protein by Claudio Graziani, Anna Barile, Alessia Parroni, Martino Luigi di Salvo, Irene De Cecio, Teresa Colombo, Jill Babor, Valérie de Crécy‐Lagard, Roberto Contestabile, Angela Tramonti (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11602438.txt.
Description
Claudio Graziani and nine co-authors report that a familiar vitamin-handling protein also grabs RNA, in a 2024 study. The protein binds pyridoxal phosphate, the active form of vitamin B6, and appears in nearly all living things. Its bacterial version, YggS, is the best studied, while faults in the human version cause a severe newborn epilepsy that responds to B6. What the protein actually does in the cell was entirely unknown.
The study shows YggS binds RNA, and that the vitamin changes how strongly it holds on. One unchanging amino acid, far from the vitamin pocket, proved central to the grip. A second job in RNA handling reframes this protein from a passive carrier into an active player worth fresh study.
Catalog record
| CREATOR | Claudio Graziani, Anna Barile, Alessia Parroni, Martino Luigi di Salvo, Irene De Cecio, Teresa Colombo, Jill Babor, Valérie de Crécy‐Lagard, Roberto Contestabile, Angela Tramonti |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 80 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |