DNA methylation analysis of peripheral blood mononuclear cells in diagnosing breast cancer from benign breast lesions
Ying Zhang, Lei Cheng · 2024
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Description
Ying Zhang and Lei Cheng test a blood-based way to tell breast cancer from harmless breast lumps. Their 2024 study reads DNA methylation in white blood cells. Telling benign nodules from cancer is a growing clinical challenge. Immune cell DNA marks shift as disease progresses, offering a possible signal.
A genome-wide array scanned methylation in patients with cancer and with benign lumps. Three marker sites stood out and were confirmed by other assays. A model built on the three markers separated the groups well. A second, separate patient group confirmed the accuracy. Extra checks aimed the test at real clinic use. A blood draw could one day spare some women deeper workups.
Catalog record
| CREATOR | Ying Zhang, Lei Cheng |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |