Zinc-Based Nanoparticles, but Not Silicon-Based Nanoparticles, Accumulate in Mitochondria and Promote Cell Death in Liver Cancer Cells
Joana C Pieretti, Thaissa L Horne, Natalia García-Villasante, Amedea B Seabra, Jordi Muntané · 2024
Read Zinc-Based Nanoparticles, but Not Silicon-Based Nanoparticles, Accumulate in Mitochondria and Promote Cell Death in Liver Cancer Cells by Joana C Pieretti, Thaissa L Horne, Natalia García-Villasante, Amedea B Seabra, Jordi Muntané (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11600939.txt.
Description
Joana Pieretti and co-authors compared two metal oxide nanoparticles for killing liver cancer cells, in a study published in 2024. Zinc oxide and silicon oxide particles are popular drug carriers, but their own effects on cells differ. The team dosed two liver cancer cell lines across a range of concentrations. Microscopy tracked where the particles ended up inside the cells, and assays measured death and breathing rates.
Zinc oxide particles cut survival in both lines, while silicon oxide particles did not. The zinc particles scattered widely and piled up in mitochondria, the cells' power plants, slowing their oxygen use. The more aggressive cell line proved more sensitive to zinc. Death came by different routes in the two lines, orderly apoptosis in one and a mixed form in the other. Silicon particles sat harmlessly in storage sacs. The authors favor zinc oxide as an active ingredient, not just a carrier.
Catalog record
| CREATOR | Joana C Pieretti, Thaissa L Horne, Natalia García-Villasante, Amedea B Seabra, Jordi Muntané |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |