Bioinformatics Analysis and Experimental Validation to Identify Key Glycosylation-Related Genes in Asthma
Yue Li, Ruhao Wu, Xiaoying Tian, Mengting Zhang, Zhe Cheng · 2024
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Description
Yue Li and co-authors report a 2024 study that hunts for genes tied to asthma through a sugar-coating process on proteins. Asthma is a long-term airway disease shaped by genes and the environment together. The role of this coating process, called glycosylation, in asthma had not been mapped before.
The team mined a public gene data set with network and enrichment tools to find candidate genes. Six key genes stood out, among them FUT5, FUT3, and B3GNT6. A second data set and lab tests on airway cells backed the picks. In cells provoked with two immune signals, four of the genes rose and two fell. The authors also matched gene levels with patient traits, pointing to fresh targets for asthma research.
Catalog record
| CREATOR | Yue Li, Ruhao Wu, Xiaoying Tian, Mengting Zhang, Zhe Cheng |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |