Multifunctional nanocomposites utilizing ruthenium (II) complex/manganese (IV) dioxide nanoparticle for synergistic reinforcing radioimmunotherapy
Jian Peng, Dong-Ling Quan, Guang Yang, Lin-Tao Wei, Zhuan Yang, Zhi-Ying Dong, Yi-Ming Zou, Ying-Ke Hou, Jin-Xiang Chen, Lin Lv, Bin Sun · 2024
Read Multifunctional nanocomposites utilizing ruthenium (II) complex/manganese (IV) dioxide nanoparticle for synergistic reinforcing radioimmunotherapy by Jian Peng, Dong-Ling Quan, Guang Yang, Lin-Tao Wei, Zhuan Yang, Zhi-Ying Dong, Yi-Ming Zou, Ying-Ke Hou, Jin-Xiang Chen, Lin Lv, Bin Sun (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11600833.txt.
Description
Jian Peng and co-authors arm radiation with a nanoparticle cocktail so a moderate dose can wake the immune system in this 2024 paper. Radiotherapy is a breast cancer mainstay, but high doses suppress immunity while moderate doses kill too few cells to alarm it. The tumor's low oxygen also blunts the attack.
Their platform packs a ruthenium complex into folate-tagged fat bubbles alongside protein-coated manganese dioxide particles. The mix gathers in tumors, raises reactive oxygen output, and relieves oxygen starvation. At a moderate four-gray dose it amplified a key alarm pathway that calls in killer T cells, far beyond what the dose alone achieves. Immune memory strengthened, and suppressive tumor macrophages flipped to an attacking type. The authors present the design as the first ruthenium-based radioimmunotherapy of its kind.
Catalog record
| CREATOR | Jian Peng, Dong-Ling Quan, Guang Yang, Lin-Tao Wei, Zhuan Yang, Zhi-Ying Dong, Yi-Ming Zou, Ying-Ke Hou, Jin-Xiang Chen, Lin Lv, Bin Sun |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |