Purified α-Amylase from Bacillus cereus exhibits antibiofilm and antiquorum sensing activities against uropathogenic Escherichia coli, Downregulating fimH, and papC virulence genes: implications for urinary tract infections
Amal M. Abo-Kamar, Abd-El-Rahman A. Mustafa, Lamiaa A. Al-Madboly · 2024
Read Purified α-Amylase from Bacillus cereus exhibits antibiofilm and antiquorum sensing activities against uropathogenic Escherichia coli, Downregulating fimH, and papC virulence genes: implications for urinary tract infections by Amal M. Abo-Kamar, Abd-El-Rahman A. Mustafa, Lamiaa A. Al-Madboly (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11600819.txt.
Description
Urinary tract infections grow harder to treat when the bacteria wall themselves into biofilms, and a humble starch-cutting enzyme might tear those walls down. Amal Abo-Kamar and co-authors purified alpha-amylase from a Bacillus strain in 2024 and tested it against the Escherichia coli strains that infect the urinary tract. The enzyme killed the bacteria at modest doses and stopped biofilms from forming.
Under the microscope, treated biofilms thinned by over half. The enzyme also jammed the bacteria's quorum sensing chatter, turning down two genes they use to grip surfaces. The authors propose the enzyme as a natural biofilm fighter that could complement antibiotics, attacking the fortress rather than only the soldiers inside it.
Catalog record
| CREATOR | Amal M. Abo-Kamar, Abd-El-Rahman A. Mustafa, Lamiaa A. Al-Madboly |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |