METTL2B m3C RNA transferase: oncogenic role in ovarian cancer progression via regulation of the mTOR/AKT pathway and its link to the tumor immune microenvironment
Yizi Meng, Yimei Meng, Hui Zheng, Jinru Huo, Peiling Li, Yanhong Shan, Jin He · 2024
Read METTL2B m3C RNA transferase: oncogenic role in ovarian cancer progression via regulation of the mTOR/AKT pathway and its link to the tumor immune microenvironment by Yizi Meng, Yimei Meng, Hui Zheng, Jinru Huo, Peiling Li, Yanhong Shan, Jin He (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11600782.txt.
Description
Yizi Meng and co-authors present a 2024 study on an RNA-editing enzyme that drives ovarian cancer. The enzyme, METTL2B, tags RNA with a chemical mark, and abnormal levels appear in several cancers. Its role in ovarian cancer was largely unexplored.
Mining three public databases, the team found the enzyme strongly overproduced in ovarian tumors, with lower levels tied to better survival. Cell and animal tests showed it speeds growth, movement, and invasion. It acts through a major growth pathway, mTOR and AKT, and its level also tracks with the immune makeup around the tumor. Drug sensitivity data linked the enzyme to treatment response. The authors propose it as a diagnostic, prognostic, and drug target candidate.
Catalog record
| CREATOR | Yizi Meng, Yimei Meng, Hui Zheng, Jinru Huo, Peiling Li, Yanhong Shan, Jin He |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |