Erianin inhibits the progression of DDP-resistant lung adenocarcinoma by regulating the Wnt/β-catenin pathway and activating the caspase-3 for apoptosis in vitro and in vivo
Lingxue Tang, Yiling Ruan, Beibei Wang, Mingjun Zhang, Jie Xue, Tong Wang · 2024
Read Erianin inhibits the progression of DDP-resistant lung adenocarcinoma by regulating the Wnt/β-catenin pathway and activating the caspase-3 for apoptosis in vitro and in vivo by Lingxue Tang, Yiling Ruan, Beibei Wang, Mingjun Zhang, Jie Xue, Tong Wang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11600767.txt.
Description
Lung tumors that stop answering to platinum chemotherapy need new weapons, and a compound from orchids is one candidate. Lingxue Tang and five co-authors tested erianin, a natural product from Dendrobium orchids, on drug-resistant lung adenocarcinoma cells and in animals, in a 2024 study. They measured cell growth, movement, invasion, and programmed death with a battery of standard assays.
Erianin slowed the resistant cells and cut their ability to spread. It worked through a major growth pathway, quieting the Wnt signal chain, and switched on an executioner enzyme that drives cell suicide. The authors present erianin as a promising lead against resistant lung cancer, pending much more testing.
Catalog record
| CREATOR | Lingxue Tang, Yiling Ruan, Beibei Wang, Mingjun Zhang, Jie Xue, Tong Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |