In silico prediction of the action of bromelain on PI3K/Akt signalling pathway to arrest nasopharyngeal cancer oncogenesis by targeting phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha protein
Alyaa Syafiqah Shamsuri, Edmund Ui -Hang Sim · 2024
Read In silico prediction of the action of bromelain on PI3K/Akt signalling pathway to arrest nasopharyngeal cancer oncogenesis by targeting phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha protein by Alyaa Syafiqah Shamsuri, Edmund Ui -Hang Sim (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11600585.txt.
Description
Alyaa Syafiqah Shamsuri and Edmund Ui-Hang Sim test a pineapple extract on throat cancer in a 2024 computer study. The extract, named bromelain, is known for health effects in some cancers, but its role in this throat cancer had not been probed.
The team built a model of the extract and docked it, in the computer, against five proteins that drive this cancer's growth. Scores said the extract could bind to all five, with the best grip on one protein at the heart of a key growth path. Maps of the joins showed the kinds of bonds that make a grip firm. The authors stress that the work is a prediction: it points to a path and a target for lab tests, not proof of a cure.
Catalog record
| CREATOR | Alyaa Syafiqah Shamsuri, Edmund Ui -Hang Sim |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |