Dual-modal overcoming of physical barriers for improved photodynamic cancer therapy via soft organosilica nanocapsules
Wei Lu, Yang Li, Xiaojun Zhang, Ning Wang, Dong Chen, Yatong Zhao, Guang Li, Xuzhi Shi, Xiaobo Ma, Xiaodan Su, Feng Wang, Chuqiang Shu, Kun Chen · 2024
Read Dual-modal overcoming of physical barriers for improved photodynamic cancer therapy via soft organosilica nanocapsules by Wei Lu, Yang Li, Xiaojun Zhang, Ning Wang, Dong Chen, Yatong Zhao, Guang Li, Xuzhi Shi, Xiaobo Ma, Xiaodan Su, Feng Wang, Chuqiang Shu, Kun Chen (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11600580.txt.
Description
Wei Lu and a large team design soft nanocapsules to improve light-based cancer therapy, in a 2024 paper. Tumors block drug delivery with dense tissue and abnormal blood vessels. Their capsules are soft silica spheres coated with an enzyme that digests part of that dense tissue.
Softness helped the capsules enter tumor cells better than stiff versions, and the enzyme coating helped them push deeper into tumor spheroids. Loaded with a light-activated drug, the capsules strengthened therapy in mice after injection into a vein. Gene analysis showed the treatment changed tumor genes tied to tissue breakdown and energy production. The authors present the dual design as a way past tumor barriers.
Catalog record
| CREATOR | Wei Lu, Yang Li, Xiaojun Zhang, Ning Wang, Dong Chen, Yatong Zhao, Guang Li, Xuzhi Shi, Xiaobo Ma, Xiaodan Su, Feng Wang, Chuqiang Shu, Kun Chen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |