Single‐cell dissection reveals immunosuppressive F13A1+ macrophage as a hallmark for multiple primary lung cancers
Chenglin Yang, Jiahao Qu, Jingting Wu, Songhua Cai, Wenyi Liu, Youjun Deng, Yiran Meng, Liuqing Zheng, Lishen Zhang, Li Wang, Xiaotong Guo · 2024
Read Single‐cell dissection reveals immunosuppressive F13A1+ macrophage as a hallmark for multiple primary lung cancers by Chenglin Yang, Jiahao Qu, Jingting Wu, Songhua Cai, Wenyi Liu, Youjun Deng, Yiran Meng, Liuqing Zheng, Lishen Zhang, Li Wang, Xiaotong Guo (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11600049.txt.
Description
Multiple separate lung cancers carry a distinctive immune cell signature, Chenglin Yang and co-authors report in a 2024 study. Multiple primary lung cancers are increasingly common and challenge current diagnosis and management. The molecular mechanisms behind them, and how they differ from a single primary cancer, remained largely unexplored. Immune landscapes were a natural place to look for that difference.
Single-cell RNA sequencing compared tumor and nearby tissue from both patient groups. The two cancer types shared large similarities in genetic, transcriptomic, and immune profiles, suggesting common treatments may apply. One immunosuppressive macrophage subtype, marked by the F13A1 gene, stood out as a hallmark of the multiple-primary form. Staining and external data sets confirmed the findings. Oncologists get a candidate marker.
Catalog record
| CREATOR | Chenglin Yang, Jiahao Qu, Jingting Wu, Songhua Cai, Wenyi Liu, Youjun Deng, Yiran Meng, Liuqing Zheng, Lishen Zhang, Li Wang, Xiaotong Guo |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 94 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |