Common molecular basis for MASH and hepatitis C revealed via systems biology approach
Yongwei Cheng, Zihao Song, Ye Liu, Xichao Xu, Dali Zhang, Yigui Zou, Liang Liu, Yinzhen Zeng, Wenwen Li, Daming Bai, Dongling Dai · 2024
Read Common molecular basis for MASH and hepatitis C revealed via systems biology approach by Yongwei Cheng, Zihao Song, Ye Liu, Xichao Xu, Dali Zhang, Yigui Zou, Liang Liu, Yinzhen Zeng, Wenwen Li, Daming Bai, Dongling Dai (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11599856.txt.
Description
Yongwei Cheng and ten colleagues present a 2024 systems biology study hunting shared roots of two liver diseases: fatty liver inflammation, called MASH, and hepatitis C. Both can end in cirrhosis and liver cancer, and fat buildup appears in each, yet their common machinery was unclear. The team mined three public gene datasets for genes changed in both diseases.
They found 866 shared genes, clustered around immune signaling and cytokine control. Ten hub genes stood out in the interaction network, and the authors charted the regulators and microRNAs that govern them. Screening suggested two existing drugs might help; in cell models, one of them, budesonide, calmed genes tied to fat and sugar handling. The work points to shared drug targets across the two diseases.
Catalog record
| CREATOR | Yongwei Cheng, Zihao Song, Ye Liu, Xichao Xu, Dali Zhang, Yigui Zou, Liang Liu, Yinzhen Zeng, Wenwen Li, Daming Bai, Dongling Dai |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |