Altered O-Glycans in stimulated whole saliva from patients with primary Sjögren’s syndrome and non-pSS sicca
Sarah Kamounah, Kristina A Thomsson, Christiane Elisabeth Sørensen, Eric Paul Bennett, Niclas G Karlsson, Anne Marie Lynge Pedersen · 2024
Read Altered O-Glycans in stimulated whole saliva from patients with primary Sjögren’s syndrome and non-pSS sicca by Sarah Kamounah, Kristina A Thomsson, Christiane Elisabeth Sørensen, Eric Paul Bennett, Niclas G Karlsson, Anne Marie Lynge Pedersen (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11599585.txt.
Description
Sarah Kamounah and co-authors study sugar chains in saliva from patients with Sjogren syndrome, in a 2024 paper. The syndrome dries the mouth and weakens the mouth lining barrier, which can change microbes and raise oral disease. The team compare sugar chains attached to saliva proteins in patients, in people with dry mouth from other causes, and in healthy controls.
Samples came from stimulated whole saliva. The fifty most common sugar chains were identified by mass tools and compared across groups. Both patient groups held more of one acidic sugar and less of a neutral building block than controls. Deeper analysis pointed to changes in several decoration steps and in core types. One short chain stood out in the syndrome group. The authors link the altered profile to changes in saliva flow traits and dryness symptoms.
Catalog record
| CREATOR | Sarah Kamounah, Kristina A Thomsson, Christiane Elisabeth Sørensen, Eric Paul Bennett, Niclas G Karlsson, Anne Marie Lynge Pedersen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |