Hybrid layer-by-layer assembly of AuNPs/NSF composite for electrochemical detection of miRNA-196a
Jun Ji, Gaofan Shi, Jiayi Jiang, Shu Wu, Haoyuan Su, Hongzhi Pan, Dongdong Zeng · 2024
Read Hybrid layer-by-layer assembly of AuNPs/NSF composite for electrochemical detection of miRNA-196a by Jun Ji, Gaofan Shi, Jiayi Jiang, Shu Wu, Haoyuan Su, Hongzhi Pan, Dongdong Zeng (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11599500.txt.
Description
Jun Ji and co-authors build a layered sensor film that can sniff out a tiny cancer-linked RNA strand in the lab. The target, miRNA-196a, helps doctors spot cancer early and tailor care. Catching such a short strand at faint levels calls for a very keen electrode.
Their film stacks gold nanoparticles with nano silk fibroin, a natural protein film, layer by layer through charge pull. A sulfur-tagged probe strand anchors to the gold and grabs only the matching RNA. The coated electrode then reports the catch as an electric signal. Tests show detection across a wide span down to extremely faint levels. The sensor picks the target out from near kin and stays stable over time. Cheap printed electrodes plus silk film make the design fit low-cost clinic labs.
Catalog record
| CREATOR | Jun Ji, Gaofan Shi, Jiayi Jiang, Shu Wu, Haoyuan Su, Hongzhi Pan, Dongdong Zeng |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |