USP33 is an integrin α6 deubiquitinase and promotes esophageal squamous cell carcinoma cell migration and metastasis
Qinglei Hang, Shiying Zuo, Yawen Yang, Yuanzhi Wang, Caimin Li, Wenqian Li, Jingya Guo, Sicong Hou, Haifeng Huang · 2024
Read USP33 is an integrin α6 deubiquitinase and promotes esophageal squamous cell carcinoma cell migration and metastasis by Qinglei Hang, Shiying Zuo, Yawen Yang, Yuanzhi Wang, Caimin Li, Wenqian Li, Jingya Guo, Sicong Hou, Haifeng Huang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11599434.txt.
Description
Qinglei Hang and co-authors present a 2024 study on an enzyme that helps throat cancer spread. The enzyme, USP33, strips ubiquitin tags off other proteins, which can steady them. Its role in esophageal cancer was unclear. The team checked its levels in public data and patient samples, then probed cell behavior in dishes and mice.
High levels tracked advanced stage and poor survival. The enzyme boosted how cancer cells grip, spread, and migrate on a key matrix protein, without speeding their growth. It works by binding and steadying an adhesion receptor, integrin α6. Silencing the enzyme cut migration and metastasis, mostly through that receptor. The authors name USP33 a drug target candidate for this cancer.
Catalog record
| CREATOR | Qinglei Hang, Shiying Zuo, Yawen Yang, Yuanzhi Wang, Caimin Li, Wenqian Li, Jingya Guo, Sicong Hou, Haifeng Huang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |