Hodgkin lymphoma: the role of EBV plasma viral load testing in an HIV-endemic setting
J. Opie, Z. Mohamed, D. Chetty, J. Bailey, K. Brown, E. Verburgh, D. Hardie · 2024
Read Hodgkin lymphoma: the role of EBV plasma viral load testing in an HIV-endemic setting by J. Opie, Z. Mohamed, D. Chetty, J. Bailey, K. Brown, E. Verburgh, D. Hardie (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11599344.txt.
Description
A blood test for virus shed by tumour cells could guide care in Hodgkin lymphoma, and Opie and co-authors tested it where the stakes are highest: South Africa, where HIV-linked cases abound. They enrolled sixty-eight newly diagnosed patients, measuring Epstein-Barr virus DNA in plasma and staining tumours for the virus, then followed survival.
A plasma level above a modest threshold identified virus-positive tumours with about ninety percent sensitivity and ninety-seven percent specificity. High plasma levels, a positive tumour stain, HIV infection, and age over forty-five each foreshadowed worse survival. The authors conclude plasma viral load is a promising biomarker in this setting, flagging both the tumour's viral status and the patient's outlook from a blood draw.
Catalog record
| CREATOR | J. Opie, Z. Mohamed, D. Chetty, J. Bailey, K. Brown, E. Verburgh, D. Hardie |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |