Unveiling the Role of TMPRSS2 in the Proteolytic Activation of Pandemic and Zoonotic Influenza Viruses and Coronaviruses in Human Airway Cells
Marie Schwerdtner, Luna C Schmacke, Julia Nave, Hannah Limburg, Torsten Steinmetzer, David A Stein, Hong M Moulton, Eva Böttcher-Friebertshäuser, Judy Wai Ping Yam, Sze Keong Tey · 2024
Read Unveiling the Role of TMPRSS2 in the Proteolytic Activation of Pandemic and Zoonotic Influenza Viruses and Coronaviruses in Human Airway Cells by Marie Schwerdtner, Luna C Schmacke, Julia Nave, Hannah Limburg, Torsten Steinmetzer, David A Stein, Hong M Moulton, Eva Böttcher-Friebertshäuser, Judy Wai Ping Yam, Sze Keong Tey (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11599139.txt.
Description
Marie Schwerdtner and co-authors test how much pandemic viruses depend on one human enzyme in this 2024 paper. Flu and corona viruses must have a surface protein cut before they can infect cells. In human airway cells, the enzyme TMPRSS2 does that cutting for many strains, which makes it a drug target candidate.
The team lowered the enzyme's activity in airway cells and infected them with several viruses. The 1918 flu strain and one bird flu subtype depended on the enzyme, while two other subtypes did not. A MERS virus was strongly suppressed, and the SARS virus was less dependent. The authors conclude that reliance on this enzyme varies by virus.
Catalog record
| CREATOR | Marie Schwerdtner, Luna C Schmacke, Julia Nave, Hannah Limburg, Torsten Steinmetzer, David A Stein, Hong M Moulton, Eva Böttcher-Friebertshäuser, Judy Wai Ping Yam, Sze Keong Tey |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |