A Comparison of the Sensitivity and Cellular Detection Capabilities of Magnetic Particle Imaging and Bioluminescence Imaging
Sophia Trozzo, Bijita Neupane, Paula J. Foster · 2024
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Description
Sophia Trozzo, Bijita Neupane and Paula Foster compared in 2024 two ways of tracking labeled cells in living animals. One way, bioluminescence, reads light from cells engineered to glow. The other, magnetic particle imaging, detects iron oxide particles directly. Mouse breast cancer cells carried both labels, then were imaged in dishes and after injection under the skin.
In cell samples, both signals tracked cell number closely. In living mice, each method hit limits. Fur, depth and scattered light hid the glow for some animals. The magnetic method's background swamped small cell numbers, and counts could not be read exactly from body images. The authors say knowing these weak points is the first step to fixes. They favor combining methods so each covers the other's blind spots.
Catalog record
| CREATOR | Sophia Trozzo, Bijita Neupane, Paula J. Foster |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |