Integrated Approach to Cyclopiazonic Acid Cytotoxicity Using In Vitro (2D and 3D Models) and In Silico Methods
Carmen Martínez-Alonso, Luana Izzo, Yelko Rodríguez-Carrasco, María-José Ruiz · 2024
Read Integrated Approach to Cyclopiazonic Acid Cytotoxicity Using In Vitro (2D and 3D Models) and In Silico Methods by Carmen Martínez-Alonso, Luana Izzo, Yelko Rodríguez-Carrasco, María-José Ruiz (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11598133.txt.
Description
A mold toxin found in fruit, cereals, and nuts can poison nerve cells, and flat cell cultures may flatter or exaggerate its danger. Carmen Martínez-Alonso and co-authors compare culture styles for cyclopiazonic acid in a 2024 study. Human neuroblastoma cells grew as ordinary monolayers and as three-dimensional spheroids, dosed for one to three days.
Killing rose with dose and time in both systems, but the spheroids consistently needed more toxin for the same harm. Exposed spheroids also lost their tidy structure and began to disaggregate. Computer models of the journey of the toxin through the body predicted strong gut absorption and entry into the brain. The authors argue risk assessment should pair the tougher 3D models with such in silico profiles.
Catalog record
| CREATOR | Carmen Martínez-Alonso, Luana Izzo, Yelko Rodríguez-Carrasco, María-José Ruiz |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |