RNA-Seq Analysis of Pubertal Mammary Epithelial Cells Reveals Novel n-3 Polyunsaturated Fatty Acid Transcriptomic Changes in the fat-1 Mouse Model
Connor D. C. Buchanan, Rahbika Ashraf, Lyn M. Hillyer, Wangshu Tu, Jing X. Kang, Sanjeena Subedi, David W. L. Ma · 2024
Read RNA-Seq Analysis of Pubertal Mammary Epithelial Cells Reveals Novel n-3 Polyunsaturated Fatty Acid Transcriptomic Changes in the fat-1 Mouse Model by Connor D. C. Buchanan, Rahbika Ashraf, Lyn M. Hillyer, Wangshu Tu, Jing X. Kang, Sanjeena Subedi, David W. L. Ma (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11597760.txt.
Description
Connor Buchanan and co-authors study gene activity in 2024 in the breast tissue cells of young mice fed healthy fats for life. Early diet may shape later breast cancer risk, and fats from fish are thought to guard the gland, but their action inside single cell types was unclear. The team used mice that make these fats in their own bodies.
They read gene activity in the lining cells of the gland during puberty. Nine genes changed clearly under both analysis methods used. The changes pointed to stronger hormone signaling and sugar use, plus better guarding of immune response and DNA repair. The pilot study suggests early fat exposure primes the cells in protective ways.
Catalog record
| CREATOR | Connor D. C. Buchanan, Rahbika Ashraf, Lyn M. Hillyer, Wangshu Tu, Jing X. Kang, Sanjeena Subedi, David W. L. Ma |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |