Recent Advances in Peptide Drug Discovery: Novel Strategies and Targeted Protein Degradation
Katarina Vrbnjak, Raj Nayan Sewduth, Avi Domb · 2024
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Description
Vrbnjak and co-authors wrote a 2024 review of recent advances in discovering peptide drugs. Peptides can grip the flat contact surfaces between proteins, a class of targets that standard small drugs handle poorly. New tools, from computer-aided design to gene editing and fast screening, have sped the hunt and cut its cost. The review covers lab and computer methods that blend data from many biological layers.
A second theme is targeted protein degradation, where a designed molecule drags a harmful protein to the cell's disposal system. Adding a peptide as the targeting part widens the range of proteins that can be attacked, including ones long called undruggable. The authors also review drugs found by these routes and the challenge of delivering peptide drugs into the body.
Catalog record
| CREATOR | Katarina Vrbnjak, Raj Nayan Sewduth, Avi Domb |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |