Distinct clinical characteristics of adolescent idiopathic scoliosis with asymmetrical ESR1 expression in paraspinal muscle progenitor cells
Hanlong Xin, Wenyuan Sui, Wenhua Mao, Junlin Yang, Xiexiang Shao · 2024
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Description
Hanlong Xin and co-authors study a gene signal in back muscle cells from girls with curved spines in a 2024 paper. The condition, called adolescent idiopathic scoliosis, has no clear single cause. Earlier work linked lower activity of the gene ESR1 on the concave side to the curve.
The team took muscle stem cells from both sides of the spine in 25 female patients. About half showed a strong left-right gap in gene activity. That group had worse curves, smaller concave-side muscle, and more fat inside that muscle. The size of the gap tracked with curve angle. The findings tie uneven muscle gene activity to how severe the curve becomes.
Catalog record
| CREATOR | Hanlong Xin, Wenyuan Sui, Wenhua Mao, Junlin Yang, Xiexiang Shao |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |