Development and Evaluation of Lactose-Free Single-Unit and Multiple-Unit Preparations of a BCS Class II Drug, Rivaroxaban
Daniel Zakowiecki, Peter Edinger, Markos Papaioannou, Michael Wagner, Tobias Hess, Jadwiga Paszkowska, Marcela Staniszewska, Daria Myslitska, Michal Smolenski, Justyna Dobosz, Grzegorz Garbacz, Dorota Haznar Garbacz, Clara Ràfols · 2024
Read Development and Evaluation of Lactose-Free Single-Unit and Multiple-Unit Preparations of a BCS Class II Drug, Rivaroxaban by Daniel Zakowiecki, Peter Edinger, Markos Papaioannou, Michael Wagner, Tobias Hess, Jadwiga Paszkowska, Marcela Staniszewska, Daria Myslitska, Michal Smolenski, Justyna Dobosz, Grzegorz Garbacz, Dorota Haznar Garbacz, Clara Ràfols (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11597082.txt.
Description
Daniel Zakowiecki and co-authors develop lactose free forms of the blood thinner rivaroxaban in this 2024 paper. The drug prevents and treats blood clots, but it dissolves poorly in water, which makes formulation hard. Many patients also avoid lactose, through intolerance or a vegan diet. The team built two forms without it: classic single tablets and modern multi pellet systems. Phosphate based fillers carried the drug in both.
Both forms passed strength tests for hardness and crumbling. They also stayed chemically stable over the study period. Dissolution tests matched the official standard for rivaroxaban tablets. The profiles also matched the reference product, Xarelto film coated tablets. The authors present the pair as proof that stable, effective forms of the drug can serve patients who need to skip lactose. They frame the work as part of a wider push for patient friendly medicines.
Catalog record
| CREATOR | Daniel Zakowiecki, Peter Edinger, Markos Papaioannou, Michael Wagner, Tobias Hess, Jadwiga Paszkowska, Marcela Staniszewska, Daria Myslitska, Michal Smolenski, Justyna Dobosz, Grzegorz Garbacz, Dorota Haznar Garbacz, Clara Ràfols |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |