Differences in Gender and Overall Survival for Temperature-Sensitive TP53 Mutations in Gastroesophageal Cancer
Danial H. Shaikh, Margaret Park, Jiandong Chen, Jeffrey Huang, Mark S. Friedman, Aamir N. Dam, Anjuli K. Luthra, Saraswathi Cappelle, Luis R. Pena, Jennifer B. Permuth, Shaffer R. S. Mok · 2024
Read Differences in Gender and Overall Survival for Temperature-Sensitive TP53 Mutations in Gastroesophageal Cancer by Danial H. Shaikh, Margaret Park, Jiandong Chen, Jeffrey Huang, Mark S. Friedman, Aamir N. Dam, Anjuli K. Luthra, Saraswathi Cappelle, Luis R. Pena, Jennifer B. Permuth, Shaffer R. S. Mok (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11597060.txt.
Description
Danial Shaikh and ten co-authors examined a special class of gene faults in cancers of the food pipe and stomach in a 2024 study. The gene TP53 is faulty in many of these cancers. Some faults make its protein unfold at body heat yet refold when cooler, a trait that drugs or cooling might exploit.
From a large cancer database, the team sorted 1,924 patients by whether their fault was heat-sensitive. Men made up over three quarters of the group, and half the samples were late stage. Heat sensitivity showed no link to a precancer condition, stage, or race. Women, though, carried heat-sensitive faults more often than men. Survival for the strongest refolders looked much like that of other faults in early reads.
Catalog record
| CREATOR | Danial H. Shaikh, Margaret Park, Jiandong Chen, Jeffrey Huang, Mark S. Friedman, Aamir N. Dam, Anjuli K. Luthra, Saraswathi Cappelle, Luis R. Pena, Jennifer B. Permuth, Shaffer R. S. Mok |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |