Repositioning Canagliflozin for Mitigation of Aluminium Chloride-Induced Alzheimer’s Disease: Involvement of TXNIP/NLRP3 Inflammasome Axis, Mitochondrial Dysfunction, and SIRT1/HMGB1 Signalling
Hemat A. Elariny, Ahmed M. Kabel, Heba Mohammed Refat M. Selim, Azza I. Helal, Doaa Abdelrahman, Hany M. Borg, Mennatallah A. Elkady, Lamees M. Dawood, Mohamed F. El-Badawy, Haifa Faisal A. Almalawi, El-Shaimaa A. Arafa, Shuruq E. Alsufyani, Hany H. Arab · 2024
Read Repositioning Canagliflozin for Mitigation of Aluminium Chloride-Induced Alzheimer’s Disease: Involvement of TXNIP/NLRP3 Inflammasome Axis, Mitochondrial Dysfunction, and SIRT1/HMGB1 Signalling by Hemat A. Elariny, Ahmed M. Kabel, Heba Mohammed Refat M. Selim, Azza I. Helal, Doaa Abdelrahman, Hany M. Borg, Mennatallah A. Elkady, Lamees M. Dawood, Mohamed F. El-Badawy, Haifa Faisal A. Almalawi, El-Shaimaa A. Arafa, Shuruq E. Alsufyani, Hany H. Arab (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11596744.txt.
Description
Hemat Elariny and co-authors tested whether a diabetes drug could ease Alzheimer-like damage in rats, in a 2024 paper. The drug, canagliflozin, already had known effects on cell stress and energy pathways. The team induced brain damage with aluminium chloride, a common way to mimic the disease in animals. Rats then received one of three doses of the drug, and the team measured behavior, tissue chemistry, and brain structure.
The drug brought behavior close to normal in a dose-dependent way. It strengthened antioxidant defenses and quieted an inflammatory switch in brain tissue. Signs of cell death eased, energy organelles worked better, and cleanup pathways recovered. Brain sections also looked healthier at higher doses. The results suggest the drug deserves further study as a candidate for the disease, though animal findings do not prove human benefit.
Catalog record
| CREATOR | Hemat A. Elariny, Ahmed M. Kabel, Heba Mohammed Refat M. Selim, Azza I. Helal, Doaa Abdelrahman, Hany M. Borg, Mennatallah A. Elkady, Lamees M. Dawood, Mohamed F. El-Badawy, Haifa Faisal A. Almalawi, El-Shaimaa A. Arafa, Shuruq E. Alsufyani, Hany H. Arab |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |