Von Hippel-Lindau deficiency protects the liver against ischemia/reperfusion injury through the regulation of hypoxia-inducible factor 1α and 2α
Zihao Li, Bing Yin, Yanan Xu, Chaoqun Wang, Xinglong Li, Shounan Lu, Shanjia Ke, Baolin Qian, Hongjun Yu, Miaoyu Bai, Zhongyu Li, Yongzhi Zhou, Hongchi Jiang, Yong Ma · 2024
Read Von Hippel-Lindau deficiency protects the liver against ischemia/reperfusion injury through the regulation of hypoxia-inducible factor 1α and 2α by Zihao Li, Bing Yin, Yanan Xu, Chaoqun Wang, Xinglong Li, Shounan Lu, Shanjia Ke, Baolin Qian, Hongjun Yu, Miaoyu Bai, Zhongyu Li, Yongzhi Zhou, Hongchi Jiang, Yong Ma (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11596652.txt.
Description
Zihao Li and co-authors find a guard gene whose loss shields the liver in a 2024 study. When blood halts then floods back in liver work, the organ takes a wound that can kill, and what drives that wound was not full known.
The gene in view marks worn parts for the trash in lean air. In mice bred with the gene cut from the liver, the flood-back wound ran mild: less burn, less cell death. Mice with the gene forced high fared worse. The shield ran through two lean-air captains the gene holds down. Block those captains and the shield died; force them high and they paid back the harm. The authors name the gene-to-captains path a fresh aim for care.
Catalog record
| CREATOR | Zihao Li, Bing Yin, Yanan Xu, Chaoqun Wang, Xinglong Li, Shounan Lu, Shanjia Ke, Baolin Qian, Hongjun Yu, Miaoyu Bai, Zhongyu Li, Yongzhi Zhou, Hongchi Jiang, Yong Ma |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |