In Vitro Cell Model Investigation of Alpha-Synuclein Aggregate Morphology Using Spectroscopic Imaging
Priyanka Swaminathan, Therése Klingstedt, Vasileios Theologidis, Hjalte Gram, Johan Larsson, Lars Hagen, Nina B. Liabakk, Odrun A. Gederaas, Per Hammarström, K. Peter R. Nilsson, Nathalie Van Den Berge, Mikael Lindgren · 2024
Read In Vitro Cell Model Investigation of Alpha-Synuclein Aggregate Morphology Using Spectroscopic Imaging by Priyanka Swaminathan, Therése Klingstedt, Vasileios Theologidis, Hjalte Gram, Johan Larsson, Lars Hagen, Nina B. Liabakk, Odrun A. Gederaas, Per Hammarström, K. Peter R. Nilsson, Nathalie Van Den Berge, Mikael Lindgren (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11594916.txt.
Description
Priyanka Swaminathan and co-authors present a cell method to study protein clump shapes in this 2024 paper. A protein called alpha-synuclein forms clumps in diseases such as Parkinson's disease. The shape of those clumps may match distinct disease types, but direct proof is lacking because shapes are hard to read.
Their method uses human cells in a dish that make the normal protein or a variant form. A glowing dye that binds amyloid clumps gives a light signature that shifts with clump shape. Cells were fed ready-made clumps, and the new clumps that formed inside were read by their light pattern and glow lifetime. The approach offers a way to sort clump types in the lab.
Catalog record
| CREATOR | Priyanka Swaminathan, Therése Klingstedt, Vasileios Theologidis, Hjalte Gram, Johan Larsson, Lars Hagen, Nina B. Liabakk, Odrun A. Gederaas, Per Hammarström, K. Peter R. Nilsson, Nathalie Van Den Berge, Mikael Lindgren |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |