Interaction Between Early Meals (Big-Breakfast Diet), Clock Gene mRNA Expression, and Gut Microbiome to Regulate Weight Loss and Glucose Metabolism in Obesity and Type 2 Diabetes
Daniela Jakubowicz, Yael Matz, Zohar Landau, Rachel Chava Rosenblum, Orit Twito, Julio Wainstein, Shani Tsameret · 2024
Read Interaction Between Early Meals (Big-Breakfast Diet), Clock Gene mRNA Expression, and Gut Microbiome to Regulate Weight Loss and Glucose Metabolism in Obesity and Type 2 Diabetes by Daniela Jakubowicz, Yael Matz, Zohar Landau, Rachel Chava Rosenblum, Orit Twito, Julio Wainstein, Shani Tsameret (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11594859.txt.
Description
Daniela Jakubowicz and six co-authors review how meal timing, body clocks, and gut microbes interact, in a 2024 paper. The body's clock genes keep daily rhythms in metabolism and take cues from light and from eating. A big breakfast resets those clocks strongly, while skipping breakfast can leave meals and clocks out of step, a pattern linked to obesity and type 2 diabetes.
Gut microbes also rise and fall across the day, and their products feed back on the clock genes. Loading calories early in the day lifts the activity of metabolic clock genes and has eased weight loss and blood sugar control in studies. Disorder in the gut can in turn knock the clocks off rhythm. The authors argue that aligning meals with the body clock can resync both systems at once.
Catalog record
| CREATOR | Daniela Jakubowicz, Yael Matz, Zohar Landau, Rachel Chava Rosenblum, Orit Twito, Julio Wainstein, Shani Tsameret |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |