Extrinsic and Cell-Intrinsic Stress in the Immune Tumor Micro-Environment
Aldo Ummarino, Nicholas Calà, Paola Allavena, Arcangelo Liso, Massimo Conese, Karel Smetana · 2024
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Description
Aldo Ummarino and co-authors review stress responses inside tumors in a 2024 paper. A growing tumor is a hostile place: food and oxygen run short, waste builds up, and swelling persists. Cancer cells survive by switching on an ancient stress program that rewires how they work.
That program also shapes the normal cells nearby, including the immune cells that enter the tumor. The review maps the main stress pathways in both cancer and immune cells and how they interact. Knowing which pathways fire under stress could reveal new drug targets, since easing or blocking the stress response might slow the disease. The authors present this as a growing frontier in cancer immunotherapy research.
Catalog record
| CREATOR | Aldo Ummarino, Nicholas Calà, Paola Allavena, Arcangelo Liso, Massimo Conese, Karel Smetana |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |