ICOSLG Is Associated with Anti-PD-1 and Concomitant Antihistamine Treatment Response in Advanced Melanoma
Domenico Mallardo, Mario Fordellone, Margaret Ottaviano, Giuseppina Marano, Maria Grazia Vitale, Mario Mallardo, Mariagrazia Capasso, Teresa De Cristofaro, Mariaelena Capone, Teresa Meinardi, Miriam Paone, Patrizia Sabatelli, Rosaria De Filippi, Alessandra Cesano, Ernesta Cavalcanti, Corrado Caracò, · 2024
Read ICOSLG Is Associated with Anti-PD-1 and Concomitant Antihistamine Treatment Response in Advanced Melanoma by Domenico Mallardo, Mario Fordellone, Margaret Ottaviano, Giuseppina Marano, Maria Grazia Vitale, Mario Mallardo, Mariagrazia Capasso, Teresa De Cristofaro, Mariaelena Capone, Teresa Meinardi, Miriam Paone, Patrizia Sabatelli, Rosaria De Filippi, Alessandra Cesano, Ernesta Cavalcanti, Corrado Caracò, (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11594639.txt.
Description
Domenico Mallardo and a large team seek a gene marker for when an allergy pill boosts melanoma immunotherapy, in a study from twenty twenty-four. Their earlier work showed patients given the antihistamine cetirizine alongside checkpoint drugs fared better. This backward-looking study hunted for what set the responders apart.
Gene activity scans pointed to one gene, a ligand that switches on a T-cell helper. Higher levels tracked with better disease control when the drug pairing was used. The gene also tracked with a marker of a friendly macrophage type, but only in patients who received the antihistamine. The authors propose the gene as a predictor for who gains from adding the pill.
Catalog record
| CREATOR | Domenico Mallardo, Mario Fordellone, Margaret Ottaviano, Giuseppina Marano, Maria Grazia Vitale, Mario Mallardo, Mariagrazia Capasso, Teresa De Cristofaro, Mariaelena Capone, Teresa Meinardi, Miriam Paone, Patrizia Sabatelli, Rosaria De Filippi, Alessandra Cesano, Ernesta Cavalcanti, Corrado Caracò, |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |