Dimer-monomer transition defines a hyper-thermostable peptidoglycan hydrolase mined from bacterial proteome by lysin-derived antimicrobial peptide-primed screening
Li Zhang, Fen Hu, Zirong Zhao, Xinfeng Li, Mingyue Zhong, Jiajun He, Fangfang Yao, Xiaomei Zhang, Yuxuan Mao, Hongping Wei, Jin He, Hang Yang, Bavesh D Kana, Li Zhang, Fen Hu, Zirong Zhao, Xinfeng Li, Mingyue Zhong, Jiajun He, Fangfang Yao, Xiaomei Zhang, Yuxuan Mao, Hongping Wei, Jin He, Hang Yang · 2024
Read Dimer-monomer transition defines a hyper-thermostable peptidoglycan hydrolase mined from bacterial proteome by lysin-derived antimicrobial peptide-primed screening by Li Zhang, Fen Hu, Zirong Zhao, Xinfeng Li, Mingyue Zhong, Jiajun He, Fangfang Yao, Xiaomei Zhang, Yuxuan Mao, Hongping Wei, Jin He, Hang Yang, Bavesh D Kana, Li Zhang, Fen Hu, Zirong Zhao, Xinfeng Li, Mingyue Zhong, Jiajun He, Fangfang Yao, Xiaomei Zhang, Yuxuan Mao, Hongping Wei, Jin He, Hang Yang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11594527.txt.
Description
Li Zhang and a team of co-authors mined a bacterium's protein set for a heat proof enzyme. Their paper, from twenty twenty-four, deals with lysins, enzymes from phages that chew the cell walls of bacteria. Such enzymes are eyed as antibiotic stand ins, since they kill direct and spark little resistance. Finds are capped by the few phage genomes at hand. The team used a peptide cut from a known lysin as a search key in a bacterial proteome.
The screen netted five wall chewing enzymes from one hard to treat bacterium. Two stood out, and one showed a pair to single unit shift that marks huge heat stability. Readers who hunt new antimicrobials get a mining route that skips the phage genome gap.
Catalog record
| CREATOR | Li Zhang, Fen Hu, Zirong Zhao, Xinfeng Li, Mingyue Zhong, Jiajun He, Fangfang Yao, Xiaomei Zhang, Yuxuan Mao, Hongping Wei, Jin He, Hang Yang, Bavesh D Kana, Li Zhang, Fen Hu, Zirong Zhao, Xinfeng Li, Mingyue Zhong, Jiajun He, Fangfang Yao, Xiaomei Zhang, Yuxuan Mao, Hongping Wei, Jin He, Hang Yang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 88 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |