Neuronal TCF7L2 in Lateral Habenula Is Involved in Stress-Induced Depression
Xincheng Li, Xiaoyu Liu, Jiaxin Liu, Fei Zhou, Yunluo Li, Ye Zhao, Xueyong Yin, Yun Shi, Haishui Shi, Irena Nalepa, Agnieszka Zelek-Molik · 2024
Read Neuronal TCF7L2 in Lateral Habenula Is Involved in Stress-Induced Depression by Xincheng Li, Xiaoyu Liu, Jiaxin Liu, Fei Zhou, Yunluo Li, Ye Zhao, Xueyong Yin, Yun Shi, Haishui Shi, Irena Nalepa, Agnieszka Zelek-Molik (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11594340.txt.
Description
Xincheng Li and co-authors link a gene regulator in a small brain hub to stress-driven depression, in a 2024 paper. The lateral habenula steers mood and disappointment signals. Its overactivity ties to depressive behavior in animals. The regulator TCF7L2 belongs to a broad signaling pathway.
Stressed male mice showed less TCF7L2 in habenula neurons. Gene knockdown and boost tools were delivered by virus. Behavior tests tracked the depressive-like changes. Drug interventions probed the receptor side of the circuit. The hub regulator pair may offer a fresh antidepressant target. Human imaging work would be the next test of the pathway outside mice.
Catalog record
| CREATOR | Xincheng Li, Xiaoyu Liu, Jiaxin Liu, Fei Zhou, Yunluo Li, Ye Zhao, Xueyong Yin, Yun Shi, Haishui Shi, Irena Nalepa, Agnieszka Zelek-Molik |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |