Mechanism of Metal Complexes in Alzheimer’s Disease
Yi Liu, Jiaying Ma, Qianling Zhang, Yi Wang, Qi Sun, José Marco-Contelles · 2024
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Description
Yi Liu and co-authors review metal complexes as candidate drugs for Alzheimer's disease, in this 2024 paper. The disease piles up amyloid and tangles tau, and today's few drugs ease symptoms without slowing the course. Metal compounds offer fresh angles, since metals sit at the heart of several of the disease's paths.
The review sorts the field by metal: ruthenium, platinum, zinc, vanadium, copper, magnesium, and more. Their tricks include blocking amyloid clumping and its cell harm, cutting tau's tangle and over-tagging, and rebalancing synapses and messengers. The authors gather the modes of action as a design brief for a drug that might at last bend the disease's course.
Catalog record
| CREATOR | Yi Liu, Jiaying Ma, Qianling Zhang, Yi Wang, Qi Sun, José Marco-Contelles |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |