MIR27A rs895819 CC Genotype Severely Reduces miR-27a Plasma Expression Levels
Georgia Ragia, Myria Pallikarou, Chrysoula Michou, Vangelis G Manolopoulos, Ilya Ioshikhes · 2024
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Description
Georgia Ragia and co-authors present a 2024 study on a gene variant and levels of a small RNA in blood. The variant sits in the gene for that RNA, which reins in an enzyme that breaks down a class of cancer drugs. Too little enzyme can make those drugs toxic. Whether the variant changes RNA levels was unclear, with clashing reports.
The team tested 59 people with no cancer history. One rare genotype, held by about five percent, came with sharply lower RNA levels. Other genotype groups did not differ from each other. The effect showed under a recessive pattern only. The authors say the finding may matter for drug safety: carriers could face lower toxicity risk. More study in cancer patients is warranted.
Catalog record
| CREATOR | Georgia Ragia, Myria Pallikarou, Chrysoula Michou, Vangelis G Manolopoulos, Ilya Ioshikhes |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |