Adverse Events as a Function of Biological Sex in a Multicenter Clinical Trial of Melanoma Vaccines
Catherine E Lyons, Ruyun Jin, Aaron D Smith, Hong Zhu, Craig L Slingluff, Eduardo Nagore · 2024
Read Adverse Events as a Function of Biological Sex in a Multicenter Clinical Trial of Melanoma Vaccines by Catherine E Lyons, Ruyun Jin, Aaron D Smith, Hong Zhu, Craig L Slingluff, Eduardo Nagore (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11592796.txt.
Description
Women are often assumed to suffer more side effects from immune treatments, as they do from autoimmune disease itself. Catherine Lyons and co-authors tested that assumption in 2024 inside a melanoma vaccine trial of 167 patients with high-risk disease. Two multi-peptide vaccines were in play, and every treatment-related side effect was graded and compared between the sexes, with care for the many comparisons involved.
Raw gaps between men and women mostly melted away after correction. Two effects, high blood sugar and skin lightening, actually graded worse in men. In adjusted models the vaccine strategy, not the patient's sex, predicted side effects. The authors conclude the vaccines looked safe for both sexes.
Catalog record
| CREATOR | Catherine E Lyons, Ruyun Jin, Aaron D Smith, Hong Zhu, Craig L Slingluff, Eduardo Nagore |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 21 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |